Structure+from+Angular+Correlations+of+Scattered+Intensities

Structure from Angular Correlations of Scattered Intensities

D. K. Saldin Department of Physics University of Wisconsin-Milwaukee

We will discuss how the study of angular correlations between scattered intensities opens up new possibilities for the structure determination of particles, such as molecules, from scattering by ensembles in which they may be in random orientations and in random relative positions, such as in natural biological environments, e.g. in cell membranes or in liquid solution. Scattering by an ensemble of particles may also allow the dose on each individual particle to be kept below the damage threshold, possibly allowing the pump-probe study of ultrafast structural changes, such as those involved in chemical reactions. We will also examine how even partial alignment of the particles may assist structure solution, and discuss prospects for the use of such methods for proposed experiments at new light sources, such as free-electron lasers.